In Journal of neurotrauma
Combat military and civilian law enforcement personnel may be exposed to repetitive low-intensity blast events during training and operations. Individuals who use explosives to gain entry (i.e., breach) into buildings are known as "breachers" or dynamic entry personnel. Breachers operate under the guidance of established safety protocols, but despite these precautions, breachers who are exposed to low-level blast throughout their careers frequently report performance deficits and symptoms to healthcare providers. While little is known about the etiology linking blast exposure to clinical symptoms in humans, animal studies demonstrate network-level changes in brain function, alterations in brain morphology, vascular and inflammatory changes, hearing loss and even alterations in gene expression following repeated blast exposure. To explore whether similar effects occur in humans, we collected a comprehensive data battery from 20 experienced breachers exposed to blast throughout their careers and 14 military and law enforcement controls. This battery included neuropsychological assessments, blood biomarkers, and magnetic resonance imaging (MRI) measures, including cortical thickness, diffusion tensor imaging of white matter, functional connectivity, and perfusion. To better understand the relationship between repetitive low-level blast exposure and behavioral and imaging differences in humans, we analyzed the data using symmetric multiview linear reconstruction (SyMLR). SyMLR is specifically designed for multiple modality statistical integration using dimensionality-reduction techniques for studies with high-dimensional, yet sparse data (i.e., low number of subjects and many data per subject). We identify significant group effects in these data spanning brain structure, function, and blood biomarkers.
Stone James R, Avants Brian B, Tustison Nicholas, Wassermann Eric, Gill Jessica, Polejaeva Elena, Dell Kristine C, Carr Walter, Yarnell Angela M, LoPresti Matthew L, Walker Peter B, O’Brien Meghan, Domeisen Natalie, Quick Alycia, Modica Claire M, Hughes John D, Haran Francis Jay, Goforth Carl Weston, Ahlers Stephen
MILITARY INJURY, MRI, PROSPECTIVE STUDY, RADIOLOGY