In Current opinion in systems biology
Deep learning is a powerful tool for predicting transcription factor binding sites from DNA sequence. Despite their high predictive accuracy, there are no guarantees that a high-performing deep learning model will learn causal sequence-function relationships. Thus a move beyond performance comparisons on benchmark datasets is needed. Interpreting model predictions is a powerful approach to identify which features drive performance gains and ideally provide insight into the underlying biological mechanisms. Here we highlight timely advances in deep learning for genomics, with a focus on inferring transcription factors binding sites. We describe recent applications, model architectures, and advances in local and global model interpretability methods, then conclude with a discussion on future research directions.
Koo Peter K, Ploenzke Matt
Deep learning, interpretability, motifs, neural networks, transcription factor binding