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In Journal of biophotonics

Optical coherence Doppler tomography (ODT) increasingly attracts attention because of its unprecedented advantages with respect to high contrast, capillary-level resolution and flow speed quantification. However, the trade-off between the signal-to-noise ratio (SNR) of ODT images and A-scan sampling density significantly slows down the imaging speed, constraining its clinical applications. To accelerate ODT imaging, a deep-learning-based approach is proposed to suppress the overwhelming phase noise from low sampling density. To handle the issue of limited paired training datasets, a generative adversarial network (GAN) is performed to implicitly learn the distribution underlying Doppler phase noise and to generate the synthetic data. Then a 3D based convolutional neural network (CNN) is trained and applied for image denoising. We demonstrate this approach outperforms traditional denoise methods in noise reduction and image details preservation, enabling high speed ODT imaging with low A-scan sampling density. This article is protected by copyright. All rights reserved.

Li Ang, Du Congwu, Volkow Nora D, Pan Yingtian


[cerebral capillary flow imaging, deep learning, imaging speed improvement], optical coherence Doppler tomography