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In Angewandte Chemie (International ed. in English)

Toehold-mediated DNA strand displacement offers DNA nanostructures with dynamic response capability. However, the sequence designing complexity dramatically increases as the scale of networks becomes large. We attribute this problem to toehold-mediated strand displacement is an Exact Strand Displacement (ESD), where one invader strand corresponds to one specific substrate. In this work, we propose the Fuzzy Strand Displacement (FSD), where one-to-many and many-to-one relationships are established between the invader strand and the substrate, to reduce the complexity. We have constructed four modules, Converter, Reporter, Fuzzy Detector, and Fuzzy Trigger, and demonstrate the capability of reducing complexity via a sequence pattern recognition network composed of such modules. Compared to ESD, the proposed FSD can measurably reduce the sequence designing complexity in similar sequences containing situations, and thereby extends the strand displacement designing methodology.

Wang Zhiyu, Hu Yingxin, Pan Linqiang


DNA recognition, DNA structures, Enzymes, Molecular Devices