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In Geburtshilfe und Frauenheilkunde

This review is intended to present the latest developments in the prevention and treatment of early breast cancer. The risk of breast cancer can be increasingly better characterised with large epidemiological studies on genetic and non-genetic risk factors. Through new analyses, the evidence for high-penetrance genes as well as for low-penetrance genes was able to be improved. New data on denosumab and atezolizumab are available in the neoadjuvant situation as is a pooled appraisal of numerous studies on capecitabine in the curative situation. There is also an update to the overall survival data of pertuzumab in the adjuvant situation with a longer follow-up observation period. Finally, digital medicine is steadily finding its way into science. A recently conducted study on automated breast cancer detection using artificial intelligence establishes the basis for a future review in clinical studies.

Schneeweiss Andreas, Hartkopf Andreas D, Müller Volkmar, Wöckel Achim, Lux Michael P, Janni Wolfgang, Ettl Johannes, Belleville Erik, Huober Jens, Thill Marc, Fasching Peter A, Kolberg Hans-Christian, Pöschke Patrik, Welslau Manfred, Overkamp Friedrich, Tesch Hans, Fehm Tanja N, Lüftner Diana, Schütz Florian


digital medicine, early breast cancer, immune therapy, prevention, prognosis, therapy