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In IEEE transactions on medical imaging ; h5-index 74.0

Timely and accurate auxiliary diagnosis of intracranial aneurysm can help radiologist make treatment plans quickly, saving lives and cutting costs at the same time. At present Digital Subtraction Angiography (DSA) is the gold standard for the diagnosis of intracranial aneurysm, but as radiologists interpret those imaging sequences frame by frame, misdiagnosis might occur. The utilization of computer-assisted diagnosis (CAD) can ease the burdens of radiologists and improve the detection accuracy of aneurysms. In this paper, a deep learning method is applied to detect the intracranial aneurysm in 3D Rotational Angiography (3D-RA) based on a spatial information fusion (SIF) method, and in stead of 3D vascular model, 2D image sequences are used. Given the intracranial aneurysm and vascular overlap having similar feature in the most time, rather than focusing on distinguishing them in one frame, the morphological differences between frames are considered as major feature. In the training data, consecutive frames of every imaging time series are extracted and concatenated in a specific way, so that the spatial contextual information could be embedded into a single twodimensional image. This method enables the time series with obvious correlation between frames be directly trained on 2D convolutional neural network (CNN), instead of 3D-CNN with huge computational cost. Finally, we got an accuracy of 98.89%, with sensitivity and specificity of 99.38% and 98.19% respectively, which proves the feasibility and availability of the SIF feature.

Zeng Yuwen, Liu Xinke, Xiao Nan, Li Youxiang, Jiang Yuhua, Feng Junqiang, Guo Shuxiang