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In Telemedicine journal and e-health : the official journal of the American Telemedicine Association ; h5-index 0.0

Background: To validate our deep learning algorithm (DLA) to read diabetic retinopathy (DR) retinographies. Introduction: Currently DR detection is made by retinography; due to its increasing diabetes mellitus incidence we need to find systems that help us to screen DR. Materials and Methods: The DLA was built and trained using 88,702 images from EyePACS, 1,748 from Messidor-2, and 19,230 from our own population. For validation a total of 38,339 retinographies from 17,669 patients (obtained from our DR screening databases) were read by a DLA and compared by four senior retina ophthalmologists for detecting any-DR and referable-DR. We determined the values of Cohen's weighted Kappa (CWK) index, sensitivity (S), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV), and errors type I and II. Results: The results of the DLA to detect any-DR were: CWK = 0.886 ± 0.004 (95% confidence interval [CI] 0.879-0.894), S = 0.967%, SP = 0.976%, PPV = 0.836%, and NPV = 0.996%. The error type I = 0.024, and the error type II = 0.004. Likewise, the referable-DR results were: CWK = 0.809 (95% CI 0.798-0.819), S = 0.998, SP = 0.968, PPV = 0.701, NPV = 0.928, error type I = 0.032, and error type II = 0.001. Discussion: Our DLA can be used as a high confidence diagnostic tool to help in DR screening, especially when it might be difficult for ophthalmologists or other professionals to identify. It can identify patients with any-DR and those that should be referred. Conclusions: The DLA can be valid to aid in screening of DR.

Romero-Aroca Pedro, Verges-Puig Raquel, de la Torre Jordi, Valls Aida, RelaƱo-Barambio Naiara, Puig Domenec, Baget-Bernaldiz Marc

2019-Nov-04

convolutional neural network, deep learning, diabetic retinopathy, screening of diabetic retinopathy