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In Trends in biotechnology

SpCas9 creates blunt end cuts in the genome and generates random and unpredictable mutations through error-prone repair systems. However, a growing body of recent evidence points instead to Cas9-induced staggered end generation, nonrandomness of mutations, and the predictability of editing outcomes using machine learning models.

Molla Kutubuddin A, Yang Yinong


CRISPR therapeutics, Cas9 mutagenesis, Cas9 repair outcome prediction, Cas9 staggered cut, machine learning, template-free precise editing