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In Trends in biotechnology

SpCas9 creates blunt end cuts in the genome and generates random and unpredictable mutations through error-prone repair systems. However, a growing body of recent evidence points instead to Cas9-induced staggered end generation, nonrandomness of mutations, and the predictability of editing outcomes using machine learning models.

Molla Kutubuddin A, Yang Yinong

2019-Sep-13

CRISPR therapeutics, Cas9 mutagenesis, Cas9 repair outcome prediction, Cas9 staggered cut, machine learning, template-free precise editing